The ELDORADO project aims to assess the long-term toxicity of dolutegravir and to compare its efficacy and tolerability with those of doravirine in first-line antiretroviral treatment for people living with HIV, particularly in sub-Saharan Africa.
The Objectives of the ELDORADO
Project
ELDORADO is an international, multicenter, clinical research project that aims at evaluating the toxicity of dolutegravir-based antiretroviral treatment and investigates doravirine as a potentially safer and equally virologically effective first-line alternative for PLHIV.
ELDORADO includes a randomized clinical trial, conducted across six countries on four continents: Cameroon, Côte d’Ivoire, Mozambique, Brazil, Thailand, and France, that will compare dolutegravir and doravirine in terms of:
- Virologic efficacy
- Safety (including metabolic, cardiac, and hepatic outcomes)
- Mental health and quality of life
This interdisciplinary project aims to generate high-quality evidence to inform global and national HIV treatment guidelines.
ELDORADO is supported by the Global Health EDCTP3 Joint Undertaking, Inserm-ANRS MIE, and MSD.
Countries involved
The ELDORADO project is conducted in 19 clinical sites over 6 countries
(Brazil, Cameroon, Côte d’Ivoire, France, Mozambique and Thailand).
Coordination Center
- Laboratory of clinical research on AIDS – INI FIOCRUZ
Study sites
Nova Iguaçu, Rio de Janeiro
- Hospital Geral de Nova Iguaçu
Rio de Janeiro, Rio de Janeiro
- Laboratory on Clinical research on AIDS-INI FIOCRUZ
Coordination Center
- Programme PAC-CI
Study sites
Abidjan
- Centre de prise en charge de Recherche et de Formation (CEPREF)
- Centre Médical de Suivi des Donneurs de Sang (CMSDS) - Centre National de Transfusion Sanguine (CNTS)
- CHU de Treichville, Service des Maladies Infectieuses et Tropicales (SMIT)
Coordination Center
- GHiGS / MEREVA
- INSERM UMR 1219 / IRD EMR 271
- Bordeaux University
Study sites
Bordeaux
- CHU Bordeaux Pellegrin - Service des Maladies Infectieuses et Tropicales
- CHU Bordeaux St André - Service de Médecine Interne
Montpellier
- CHU Montpellier - Hôpital La Colombière - Service des Maladies Infectieuses et Tropicales
Nantes
- CHU Nantes Hôtel Dieu - Service des Maladies infectieuses et tropicales
Paris
- AP-HP Hôpital Lariboisière - Service de Maladies Infectieuses et Tropicales
- AP-HP Hôpital Saint Louis - Service des Maladies Infectieuses et Tropicales
- AP-HP Hôpital Saint Antoine - Service des Maladies Infectieuses et Tropicales
- AP-HP Hôpital Pitié Salpêtrière - Service des Maladies Infectieuses et Tropicales
- AP-HP Bichat Claude Bernard - Service des Maladies Infectieuses et Tropicales
Coordination Center
- Site ANRS du Cameroun
Study sites
Yaoundé
- Hôpital Central de Yaoundé
Coordination Center
- Polana Caniço Health and Research Training Center (CISPOC)
-Instituto Nacional de Saúde
Study sites
Maputo
- Centro de Saúde 1o de Maio
Coordination Center
- PHPT-AMS Research Collaboration at Chiang Mai University – Faculty of Associated Medical Sciences
Study sites
Chiang Rai
- Chiangrai Prachanukroh
Lampang
- Lampang Hospital Internal Medicine department
Phayao
- Phayao Hospital Internal Medicine department
Work Packages
The Eldorado project is organized into highly interactive Work Packages (WPs) to ensure optimal implementation of all activities, from project and trial coordination to capacity building before and after the trials, including embedded studies, and especially the dissemination and utilization of results among all stakeholders.
Training Courses / Webinars
Access our training sessions and webinars dedicated to healthcare professionals, researchers, and decision-makers.
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Funders
The ELDORADO project is supported by
